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Consumer Chemicals and Containers Regulations, 2001

Version of section 36 from 2006-03-22 to 2016-06-21:


Marginal note:Additivity formulas — LD50 or LC50 of mixtures

  •  (1) The LD50 or LC50 of a mixture may be determined from the LD50 or LC50 of its ingredients that are present in a concentration of 1% or more, using one of the following additivity formulas, as the case may be:

    • (a) for a solid or a liquid

      LD50 = 1/[(Pa/LD50a)+(Pb/LD50b)+...+(Pn/LD50n)]

      where

      LD50
      represents the LD50 of the mixture,
      LD50a to LD50n
      represent the LD50 of each ingredient that is present in a concentration of 1% or more, and
      Pa to Pn
      represent the proportion by weight of each ingredient that is present in a concentration of 1% or more; or
    • (b) for a gas, vapour, dust, mist or fume

      LC50 = 1/[(Pa/LC50a)+(Pb/LC50b)+...+(Pn/LC50n)]

      where

      LC50
      represents the LC50 of the mixture,
      LC50a to LC50n
      represent the LC50 of each ingredient that is present in a concentration of 1% or more, and
      Pa to Pn
      represent the proportion by weight of each ingredient that is present in a concentration of 1% or more.
  • Marginal note:Complex mixture

    (2) For the purposes of the additivity formulas set out in subsection (1), “ingredient” includes a complex mixture.

  • Marginal note:When LD50 or LC50 of ingredient is not known but can be estimated

    (3) When the LD50 or LC50 of one or more ingredients present in a chemical product in a concentration of 1% or more is not known, the person responsible may, in the additivity formulas set out in subsection (1), use an estimated LD50 or LC50 determined in accordance with good scientific practices.

  • Marginal note:When LD50 or LC50 of ingredient is not known and cannot be estimated

    (4) When the LD50 or LC50 of one or more ingredients present in a chemical product is not known and cannot be estimated from information referred to in paragraph 35(1)(b) or (c), the person responsible, in the additivity formulas set out in subsection (1), must substitute for the LD50 or LC50 of the ingredient, the LD50 or LC50 of the most toxic known ingredient that is present in the product at a concentration of 1% or more.


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