Hazardous Products Regulations

Marginal note:Definitions

8.5 The following definitions apply in this Subpart.

genotoxicity

génotoxicité

genotoxicity means the alteration of the structure, information content or segregation of DNA by an agent or process, including those agents or processes that cause DNA damage by interfering with normal replication processes or that in a non-physiological manner temporarily alter its replication. (génotoxicité)

germ cell mutagen

mutagène des cellules germinales

germ cell mutagen means a mixture or substance that is liable to lead to an increased occurrence of mutations in the germ cells of a population. (mutagène des cellules germinales)

mutagenic

mutagène

mutagenic means, in relation to a mixture or substance, liable to lead to an increased occurrence of mutations in populations of cells or organisms. (mutagène)

mutagenicity

mutagénicité

mutagenicity means an increased occurrence of mutations in populations of cells or organisms. (mutagénicité)

mutation

mutation

mutation means a permanent change in the amount or structure of the genetic material in a cell and includes

• (a) the heritable genetic changes that may be manifested at the phenotypic level; and

• (b) the underlying DNA modifications when known, including specific base pair changes and chromosomal translocations. (mutation)