Hazardous Products Regulations

Marginal note:LD₅₀ or LC₅₀ — associated range

• 8.1.1 (1) An acute toxicant that is a substance is classified, with respect to each applicable route of exposure, in a category of this hazard class in accordance with the tables to subsection (3) if it has an LD₅₀ by the oral or dermal exposure route, or an LC₅₀ by the inhalation exposure route, that falls into one of the ranges indicated in the applicable table to that subsection.

• Marginal note:Contact with water — gaseous substance

  (2) In addition to subsection (1), an acute toxicant that is a substance is classified with respect to the inhalation route of exposure in a category of this hazard class in accordance with Table 3 to subsection (3) if upon contact with water, it releases a gaseous substance that has an LC₅₀ that falls into one of the ranges indicated in that table, unless that substance is already classified in a category of this hazard class for the inhalation route of exposure that represents a more severe hazard.

• Marginal note:LD₅₀ or LC₅₀ not available

  (3) If an LD₅₀ by the oral or dermal exposure route or an LC₅₀ by the inhalation exposure route is not available, an acute toxicity point estimate must be established in accordance with the table to section 8.1.7, and the acute toxicant must be classified based on that acute toxicity point estimate, with respect to each applicable route of exposure, in a category of this hazard class in accordance with the following tables:

  	Column 1	Column 2
  Item	Category	Ranges for LD50 or for Acute Toxicity Point Estimates (mg/kg body weight)
  1	Acute Toxicity (Oral) — Category 1	≤ 5
  2	Acute Toxicity (Oral) — Category 2	> 5 and ≤ 50
  3	Acute Toxicity (Oral) — Category 3	> 50 and ≤ 300
  4	Acute Toxicity (Oral) — Category 4	> 300 and ≤ 2000

  	Column 1	Column 2
  Item	Category	Ranges for LD50 or for Acute Toxicity Point Estimates (mg/kg body weight )
  1	Acute Toxicity (Dermal) — Category 1	≤ 50
  2	Acute Toxicity (Dermal) — Category 2	> 50 and ≤ 200
  3	Acute Toxicity (Dermal) — Category 3	> 200 and ≤ 1000
  4	Acute Toxicity (Dermal) — Category 4	> 1000 and ≤ 2000

  	Column 1	Column 2	Column 3	Column 4
  		Ranges for LC50 or for Acute Toxicity Point Estimates
  Item	Category	Gases (ppmV)	Vapours (mg/l)	Dusts and Mists (mg/l)
  1	Acute Toxicity (Inhalation) — Category 1	≤ 100	≤ 0.5	≤ 0.05
  2	Acute Toxicity (Inhalation) — Category 2	> 100 and ≤ 500	> 0.5 and ≤ 2	> 0.05 and ≤ 0.5
  3	Acute Toxicity (Inhalation) — Category 3	> 500 and ≤ 2500	> 2 and ≤ 10	> 0.5 and ≤ 1
  4	Acute Toxicity (Inhalation) — Category 4	> 2500 and ≤ 20 000	> 10 and ≤ 20	> 1 and ≤ 5

• Marginal note:One-hour exposure period

  (4) For the purposes of Table 3 to subsection (3), the LC₅₀ is based on a four-hour exposure period. If existing acute inhalation toxicity data have been generated according to a one-hour exposure period, the LC₅₀ for gases and vapours must be divided by two, and the LC₅₀ for dusts and mists must be divided by four.