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Hazardous Products Regulations

Version of section 8.1.1 from 2015-02-11 to 2022-12-14:


Marginal note:LD50 or LC50 — associated range

  •  (1) An acute toxicant that is a substance is classified, with respect to each applicable route of exposure, in a category of this hazard class in accordance with the tables to subsection (3) if it has an LD50 by the oral or dermal exposure route, or an LC50 by the inhalation exposure route, that falls into one of the ranges indicated in the applicable table to that subsection.

  • Marginal note:Contact with water — gaseous substance

    (2) In addition to subsection (1), an acute toxicant that is a substance is classified with respect to the inhalation route of exposure in a category of this hazard class in accordance with Table 3 to subsection (3) if upon contact with water, it releases a gaseous substance that has an LC50 that falls into one of the ranges indicated in that table, unless that substance is already classified in a category of this hazard class for the inhalation route of exposure that represents a more severe hazard.

  • Marginal note:LD50 or LC50 not available

    (3) If an LD50 by the oral or dermal exposure route or an LC50 by the inhalation exposure route is not available, an acute toxicity point estimate must be established in accordance with the table to section 8.1.7, and the acute toxicant must be classified based on that acute toxicity point estimate, with respect to each applicable route of exposure, in a category of this hazard class in accordance with the following tables:

    TABLE 1

    Oral Exposure Route

    Column 1Column 2
    ItemCategoryRanges for LD50 or for Acute Toxicity Point Estimates (mg/kg body weight)
    1Acute Toxicity (Oral) — Category 1≤ 5
    2Acute Toxicity (Oral) — Category 2> 5 and ≤ 50
    3Acute Toxicity (Oral) — Category 3> 50 and ≤ 300
    4Acute Toxicity (Oral) — Category 4> 300 and ≤ 2000

    TABLE 2

    Dermal Exposure Route

    Column 1Column 2
    ItemCategoryRanges for LD50 or for Acute Toxicity Point Estimates (mg/kg body weight )
    1Acute Toxicity (Dermal) — Category 1≤ 50
    2Acute Toxicity (Dermal) — Category 2> 50 and ≤ 200
    3Acute Toxicity (Dermal) — Category 3> 200 and ≤ 1000
    4Acute Toxicity (Dermal) — Category 4> 1000 and ≤ 2000

    TABLE 3

    Inhalation Exposure Route

    Column 1Column 2Column 3Column 4
    Ranges for LC50 or for Acute Toxicity Point Estimates
    ItemCategoryGases (ppmV)Vapours (mg/l)Dusts and Mists (mg/l)
    1Acute Toxicity (Inhalation) — Category 1≤ 100≤ 0.5≤ 0.05
    2Acute Toxicity (Inhalation) — Category 2> 100 and ≤ 500> 0.5 and ≤ 2> 0.05 and ≤ 0.5
    3Acute Toxicity (Inhalation) — Category 3> 500 and ≤ 2500> 2 and ≤ 10> 0.5 and ≤ 1
    4Acute Toxicity (Inhalation) — Category 4> 2500 and ≤ 20 000> 10 and ≤ 20> 1 and ≤ 5
  • Marginal note:One-hour exposure period

    (4) For the purposes of Table 3 to subsection (3), the LC50 is based on a four-hour exposure period. If existing acute inhalation toxicity data have been generated according to a one-hour exposure period, the LC50 for gases and vapours must be divided by two, and the LC50 for dusts and mists must be divided by four.


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