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Controlled Substances Regulations (SOR/2025-242)

Regulations are current to 2026-03-17

The following schedule is not in force.

SCHEDULE 1(Subsection 1(1), paragraphs 5(1)(a), 11(1)(f), 12(1)(c) and (i), 34(1)(h), 39(d), 42(1)(h), 47(d), 56(d), 57(1)(d), 58(1)(d), 59(d), 61(d), 62(d) and 69(1)(d), subparagraph 72(e)(iv), paragraphs 73(1)(g), 75(d), 76(d), 77(a), 78(b), 80(g), 81(d), 82(d), 83(b), 84(e), 85(1)(a), 92(3)(d), 93(1)(d) and (2)(e), 94(1)(d), 95(d), 97(d), 111(d), 112(d), 117(d), 120(g), 121(f), 128(2)(d), 129(d), 141(c), 142(d), 143(2)(e) and 144(c), subparagraph 144(f)(ii), paragraphs 146(f), 147(f), 154(a) and 158(3)(d), subparagraphs 159(1)(b)(iv) and 160(1)(b)(iv), paragraphs 161(1)(d) and (2)(d), 162(d), 175(d), 176(d), 177(d), 181(d), 182(g), 183(f), 205(1)(g), 210(d), 213(1)(g) and 218(d), sections 225 and 226 and paragraph 229(1)(c))Narcotics

ItemName
1Opium Poppy (Papaver somniferum), its preparations, derivatives, alkaloids and salts, including
  • (1) 
    Opium
  • (2) 
    Codeine (methylmorphine)
  • (3) 
    Morphine (7,8-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol)
  • (4) 
    Thebaine (paramorphine)
  • and the salts, derivatives and salts of derivatives of the substances set out in subitems (1) to (4), including
  • (5) 
    Acetorphine (acetyletorphine)
  • (6) 
    Acetyldihydrocodeine (4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol acetate)
  • (7) 
    Benzylmorphine (7,8-didehydro-4,5-epoxy-17-methyl-3-(phenylmethoxy) morphinan-6-ol)
  • (8) 
    Codoxime (dihydrocodeinone O-(carboxymethyl)oxime)
  • (9) 
    Desomorphine (dihydrodeoxymorphine)
  • (10) 
    Diacetylmorphine (heroin)
  • (11) 
    Dihydrocodeine (4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol)
  • (12) 
    Dihydromorphine (4,5-epoxy-17-methylmorphinan-3,6-diol)
  • (13) 
    Ethylmorphine (7,8-didehydro-4,5-epoxy-3-ethoxy-17-methylmorphinan-6-ol)
  • (14) 
    Etorphine (tetrahydro-7alpha-(1-hydroxy-1-methylbutyl)-6,14-endo-ethenooripavine)
  • (15) 
    Hydrocodone (dihydrocodeinone)
  • (16) 
    Hydromorphinol (dihydro-14-hydroxymorphine)
  • (17) 
    Hydromorphone (dihydromorphinone)
  • (18) 
    Methyldesorphine (delta-6-deoxy-6-methylmorphine)
  • (19) 
    Methyldihydromorphine (dihydro-6-methylmorphine)
  • (20) 
    Metopon (dihydromethylmorphinone)
  • (21) 
    Morphine-N-oxide (morphine oxide)
  • (22) 
    Myrophine (benzylmorphine myristate)
  • (23) 
    Nalorphine (N-allylnormorphine)
  • (24) 
    Nicocodine (6-nicotinylcodeine)
  • (25) 
    Nicomorphine (dinicotinylmorphine)
  • (26) 
    Norcodeine (N-desmethylcodeine)
  • (27) 
    Normorphine (N-desmethylmorphine)
  • (28) 
    Oxycodone (dihydrohydroxycodeinone)
  • (29) 
    Oxymorphone (dihydrohydroxymorphinone)
  • (30) 
    Pholcodine (3-[2-(4-morpholinyl)ethyl]morphine)
  • (31) 
    Thebacon (acetyldihydrocodeinone)
  • but not including
  • (32) 
    Apomorphine (5,6,6a,7-tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol) and its salts
  • (33) 
    Cyprenorphine (N-(cyclopropylmethyl)-6,7,8,14-tetrahydro-7alpha-(1-hydroxy-1-methylethyl)-6,14-endo-ethenonororipavine) and its salts
  • (34) 
    Nalmefene (17-(cyclopropylmethyl)-4,5alpha-epoxy-6-methylenemorphinan-3,14-diol) and its salts
  • (35) 
    Naloxone (4,5alpha-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one) and its salts
  • (36) 
    Naltrexone (17-(cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxymorphinan-6-one) and its salts
  • (37) 
    Methylnaltrexone (17-(cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinanium) and its salts
  • (38) 
    Naloxegol (4,5alpha-epoxy-6alpha-(3,6,9,12,15,18,21-heptaoxadocos-1-yloxy)-17-(2-propenyl)morphinan-3,14-diol) and its salts
  • (39) 
    Narcotine (6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-1(3H)-isobenzofuranone) and its salts
  • (40) 
    Papaverine (1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline) and its salts
  • (41) 
    Poppy seed
2Coca (Erythroxylum), its preparations, derivatives, alkaloids and salts, including
  • (1) 
    Coca leaves
  • (2) 
    Cocaine (benzoylmethylecgonine)
  • (3) 
    Ecgonine (3-hydroxy-2-tropane carboxylic acid)
  • but not including
  • (4) 
    123I-ioflupane
3Phenylpiperidines, their intermediates, salts, derivatives and analogues and salts of intermediates, derivatives and analogues, including
  • (1) 
    Allylprodine (3-allyl-1-methyl-4-phenyl-4-piperidinol propionate)
  • (2) 
    Alphameprodine (alpha-3-ethyl-1-methyl-4-phenyl-4-piperidinol propionate)
  • (3) 
    Alphaprodine (alpha-1,3-dimethyl-4-phenyl-4-piperidinol propionate)
  • (4) 
    Anileridine (ethyl 1-[2-(p-aminophenyl)ethyl]-4-phenylpiperidine-4-carboxylate)
  • (5) 
    Betameprodine (beta-3-ethyl-1-methyl-4-phenyl-4-piperidinol propionate)
  • (6) 
    Betaprodine (beta-1,3-dimethyl-4-phenyl-4-piperidinol propionate)
  • (7) 
    Benzethidine (ethyl 1-(2-benzyloxyethyl)-4-phenylpiperidine-4-carboxylate)
  • (8) 
    Diphenoxylate (ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate)
  • (9) 
    Difenoxin (1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate)
  • (10) 
    Etoxeridine (ethyl 1-[2-(2-hydroxyethoxy)ethyl]-4-phenylpiperidine-4-carboxylate)
  • (11) 
    Furethidine (ethyl 1-(2-tetrahydrofurfuryloxyethyl)-4-phenylpiperidine-4-carboxylate)
  • (12) 
    Hydroxypethidine (ethyl 4-(m-hydroxyphenyl)-1-methylpiperidine-4-carboxylate)
  • (13) 
    Ketobemidone (1-[4-(m-hydroxyphenyl)-1-methyl-4-piperidyl]-1-propanone)
  • (14) 
    Methylphenylisonipecotonitrile (4-cyano-1-methyl-4-phenylpiperidine)
  • (15) 
    Morpheridine (ethyl 1-(2-morpholinoethyl)-4-phenylpiperidine-4-carboxylate)
  • (16) 
    Norpethidine (ethyl 4-phenylpiperidine-4-carboxylate)
  • (17) 
    Pethidine (ethyl 1-methyl-4-phenylpiperidine-4-carboxylate)
  • (18) 
    Phenoperidine (ethyl 1-(3-hydroxy-3-phenylpropyl)-4-phenylpiperidine-4-carboxylate)
  • (19) 
    Piminodine (ethyl 1-[3-(phenylamino)propyl]-4-phenylpiperidine-4-carboxylate)
  • (20) 
    Properidine (isopropyl 1-methyl-4-phenylpiperidine-4- carboxylate)
  • (21) 
    Trimeperidine (1,2,5-trimethyl-4-phenyl-4-piperidinol propionate)
  • (22) 
    Pethidine Intermediate C (1-methyl-4-phenylpiperidine-4-carboxylate)
  • but not including
  • (23) 
    Carperidine (ethyl 1-(2-carbamylethyl)-4-phenylpiperidine-4-carboxylate) and its salts
  • (24) 
    Oxpheneridine (ethyl 1-(2-hydroxy-2-phenylethyl)-4-phenylpiperidine-4-carboxylate) and its salts
4Phenazepines, their salts, derivatives and salts of derivatives including
  • (1) 
    Proheptazine (hexahydro-1,3-dimethyl-4-phenyl-1H-azepin-4-ol propionate)
  • but not including
  • (2) 
    Ethoheptazine (ethyl hexahydro-1-methyl-4-phenylazepine-4-carboxylate) and its salts
  • (3) 
    Metethoheptazine (ethyl hexahydro-1,3-dimethyl-4-phenylazepine-4-carboxylate) and its salts
  • (4) 
    Metheptazine (methylhexahydro-1,2-dimethyl-4-phenylazepine-4-carboxylate) and its salts
5Amidones, their intermediates, salts, derivatives and salts of intermediates and derivatives, including
  • (1) 
    Dimethylaminodiphenylbutanonitrile (4-cyano-2-dimethylamino-4,4-diphenylbutane)
  • (2) 
    Dipipanone (4,4-diphenyl-6-piperidino-3-heptanone)
  • (3) 
    Isomethadone (6-dimethylamino-5-methyl-4,4-diphenyl-3-hexanone)
  • (4) 
    Methadone (6-dimethylamino-4,4-diphenyl-3-heptanone)
  • (5) 
    Normethadone (6-dimethylamino-4,4-diphenyl-3-hexanone)
  • (6) 
    Norpipanone (4,4-diphenyl-6-piperidino-3-hexanone)
  • (7) 
    Phenadoxone (6-morpholino-4,4-diphenyl-3-heptanone)
6Methadols, their salts, derivatives and salts of derivatives, including
  • (1) 
    Acetylmethadol (6-dimethylamino-4,4-diphenyl-3-heptanol acetate)
  • (2) 
    Alphacetylmethadol (alpha-6-dimethylamino-4,4-diphenyl-3-heptanol acetate)
  • (3) 
    Alphamethadol (alpha-6-dimethylamino-4,4-diphenyl-3-heptanol)
  • (4) 
    Betacetylmethadol (beta-6-dimethylamino-4,4-diphenyl-3-heptanol acetate)
  • (5) 
    Betamethadol (beta-6-dimethylamino-4,4-diphenyl-3-heptanol)
  • (6) 
    Dimepheptanol (6-dimethylamino-4,4-diphenyl-3-heptanol)
  • (7) 
    Noracymethadol (alpha-6-methylamino-4,4-diphenyl-3-heptanol acetate)
7Phenalkoxams, their salts, derivatives and salts of derivatives, including
  • (1) 
    Dimenoxadol (dimethylaminoethyl 1-ethoxy-1,1-diphenylacetate)
  • (2) 
    Dioxaphetyl butyrate (ethyl 2,2-diphenyl-4-morpholinobutyrate)
  • (3) 
    Dextropropoxyphene ([S-(R*,S*)]-alpha-[2-(dimethylamino)-1-methylethyl]-alpha-phenylbenzeneethanol, propanoate ester)
8Thiambutenes, their salts, derivatives and salts of derivatives, including
  • (1) 
    Diethylthiambutene (N,N-diethyl-1-methyl-3,3-di-2-thienylallylamine)
  • (2) 
    Dimethylthiambutene (N,N,1-trimethyl-3,3-di-2-thienylallylamine)
  • (3) 
    Ethylmethylthiambutene (N-ethyl-N,1-dimethyl-3,3-di-2-thienylallylamine)
9Moramides, their intermediates, salts, derivatives and salts of intermediates and derivatives, including
  • (1) 
    Dextromoramide (d-1-(3-methyl-4-morpholino-2,2-diphenylbutyryl)pyrrolidine)
  • (2) 
    Diphenylmorpholinoisovaleric acid (2-methyl-3-morpholino-1,1-diphenylpropionic acid)
  • (3) 
    Levomoramide (l-1-(3-methyl-4-morpholino-2,2-diphenylbutyryl)pyrrolidine)
  • (4) 
    Racemoramide (d,l-1-(3-methyl-4-morpholino-2,2-diphenylbutyryl)pyrrolidine)
10Morphinans, their salts, derivatives and salts of derivatives, including
  • (1) 
    Buprenorphine (17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-6,14-ethenomorphinan-7-methanol)
  • (2) 
    Drotebanol (6beta,14-dihydroxy-3,4-dimethoxy-17-methylmorphinan)
  • (3) 
    Levomethorphan (1-3-methoxy-17-methylmorphinan)
  • (4) 
    Levorphanol (1-3-hydroxy-17-methylmorphinan)
  • (5) 
    Levophenacylmorphan (1-3-hydroxy-17-phenacylmorphinan)
  • (6) 
    Norlevorphanol (1-3-hydroxymorphinan)
  • (7) 
    Phenomorphan (3-hydroxy-17-(2-phenylethyl)morphinan)
  • (8) 
    Racemethorphan (d,l-3-methoxy-17-methylmorphinan)
  • (9) 
    Racemorphan (d,l-3-hydroxy-N-methylmorphinan)
  • but not including
  • (10) 
    Dextromethorphan (d-1,2,3,9,10,10a-hexahydro-6-methoxy-11-methyl-4H-10,4a-iminoethanophenanthren) and its salts
  • (11) 
    Dextrorphan (d-1,2,3,9,10,10a-hexahydro-11-methyl-4H-10,4a-iminoethanophenanthren-6-ol) and its salts
  • (12) 
    Levallorphan (l-11-allyl-1,2,3,9,10,10a-hexahydro-4H-10,4a-iminoethanophenanthren-6-ol) and its salts
  • (13) 
    Levargorphan (l-11-propargyl-1,2,3,9,10,10a-hexahydro-4H-10,4a-iminoethanophenanthren-6-ol) and its salts
  • (14) 
    Butorphanol (l-N-cyclobutylmethyl-3,14-dihydroxymorphinan) and its salts
  • (15) 
    Nalbuphine (N-cyclobutylmethyl-4,5-epoxymorphinan-3,6,14-triol) and its salts
11Benzazocines, their salts, derivatives and salts of derivatives, including
  • (1) 
    Phenazocine (1,2,3,4,5,6-hexahydro-6,11-dimethyl- 3-phenethyl-2,6-methano-3-benzazocin-8-ol)
  • (2) 
    Metazocine (1,2,3,4,5,6-hexahydro-3,6,11-trimethyl-2,6-methano-3-benzazocin-8-ol)
  • (3) 
    Pentazocine (1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-2,6-methano-3-benzazocin-8-ol)
  • but not including
  • (4) 
    Cyclazocine (1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(cyclopropylmethyl)-2,6-methano-3-benzazocin-8-ol) and its salts
12Ampromides, their salts, derivatives and salts of derivatives, including
  • (1) 
    Diampromide (N-[2-(methylphenethylamino)propyl]propionanilide)
  • (2) 
    Phenampromide (N-((1-methyl-2-piperidino)ethyl)propionanilide)
  • (3) 
    Propiram (N-(1-methyl-2-piperidinoethyl)-N-2-pyridylpropionamide)
13Benzimidazoles, their salts, derivatives and salts of derivatives, including
  • (1) 
    Clonitazene (2-(p-chlorobenzyl)-1-diethylaminoethyl-5-nitrobenzimidazole)
  • (2) 
    Etonitazene (2-(p-ethoxybenzyl)-1-diethylaminoethyl-5-nitrobenzimidazole)
  • (3) 
    Bezitramide (1-(3-cyano-3,3-diphenylpropyl)-4-(2-oxo-3-propionyl-1-benzimidazolinyl)-piperidine)
14Phencyclidine (1-(1-phenylcyclohexyl)piperidine), its salts, derivatives and analogues and salts of derivatives and analogues, including
  • (1) 
    Ketamine (2-(2-chlorophenyl)-2-(methylamino)cyclohexanone)
15Fentanyls, their salts, derivatives and analogues and salts of derivatives and analogues, including
  • (1) 
    Acetyl-alpha-methylfentanyl (N-[1-(alpha-methylphenethyl)-4-piperidyl]acetanilide)
  • (2) 
    Alfentanil (N-[1-[2-(4-ethyl-4,5-dihydro-5-oxo-1H-tetrazol-1-yl)ethyl]-4-(methoxymethyl)-4-piperidyl]propionanilide)
  • (3) 
    Carfentanil (methyl 4-[(1-oxopropyl)phenylamino]-1-(2-phenethyl)-4-piperidinecarboxylate)
  • (4) 
    p-Fluorofentanyl (4′-fluoro-N-(1-phenethyl-4-piperidyl)propionanilide)
  • (5) 
    Fentanyl (N-(1-phenethyl-4-piperidyl)propionanilide)
  • (6) 
    beta-Hydroxyfentanyl (N-[1-(beta-hydroxyphenethyl)-4-piperidyl]propionanilide)
  • (7) 
    beta-Hydroxy-3-methylfentanyl (N-[1-(beta-hydroxyphenethyl)-3-methyl-4-piperidyl]propionanilide)
  • (8) 
    alpha-Methylfentanyl (N-[1-(alpha-methylphenethyl)-4-piperidyl]propionanilide)
  • (9) 
    alpha-Methylthiofentanyl (N-[1-[1-methyl-2-(2-thienyl)ethyl]-4-piperidyl]propionanilide)
  • (10) 
    3-Methylfentanyl (N-(3-methyl-1-phenethyl-4-piperidyl)propionanilide)
  • (11) 
    3-Methylthiofentanyl (N-[3-methyl-1-[2-(2-thienyl)ethyl]-4-piperidyl]propionanilide)
  • (12) 
    Remifentanil (dimethyl 4-carboxy-4-(N-phenylpropionamido)-1-piperidinepropionate)
  • (13) 
    Sufentanil (N-[4-(methoxymethyl)-1-[2-(2-thienyl)ethyl]-4-piperidyl]propionanilide)
  • (14) 
    Thiofentanyl (N-[1-[2-(2-thienyl)ethyl]-4-piperidyl]propionanilide)
  • (15) 
    4-Anilino-N-phenethylpiperidine (ANPP) (N-phenyl-1-(2-phenylethyl)piperidine-4-amine), its derivatives and analogues and salts of derivatives and analogues
16Tilidine (ethyl-2-(dimethylamino)-1-phenyl-3-cyclohexene-1-carboxylate), its salts, derivatives and salts of derivatives
17Synthetic cannabinoid receptor type 1 agonists, their salts, derivatives, isomers and salts of derivatives and isomers, including those that fall within the following core chemical structure classes, with the exception of any substance that is identical to any phytocannabinoid and of ((3S)-2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl)-1-naphthalenyl-methanone (WIN 55,212-3) and its salts:
  • (1) 
    Any substance that has a 2-(cyclohexyl)phenol structure with substitution at the 1-position of the benzene ring by a hydroxy, ether or ester group and further substituted at the 5-position of the benzene ring, whether or not further substituted on the benzene ring to any extent, and substituted at the 3’-position of the cyclohexyl ring by an alkyl, carbonyl, hydroxyl, ether or ester, and whether or not further substituted on the cyclohexyl ring to any extent, including
    • (i) 
      Nabilone ((±)-trans-3-(1,1-dimethylheptyl)-6,6a,7,8,10,10a-hexahydro-1-hydroxy-6,6-dimethyl-9H-dibenzo[b,d]pyran-9-one)
    • (ii) 
      Parahexyl (3-hexyl-6,6,9-trimethyl-7,8,9,10-tetrahydro-6H-dibenzo[b,d]pyran-1-ol)
    • (iii) 
      3-(1,2-dimethylheptyl)-7,8,9,10-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran-1-ol (DMHP)
    • (iv) 
      5-(1,1-dimethylheptyl)-2-(5-hydroxy-2-(3-hydroxypropyl)cyclohexyl)phenol (CP 55,940)
    • (v) 
      5-(1,1-dimethylheptyl)-2-(3-hydroxycyclohexyl)phenol (CP 47,497)
  • (2) 
    Any substance that has a 3-(1-naphthoyl)indole structure with substitution at the nitrogen atom of the indole ring, whether or not further substituted on the indole ring to any extent and whether or not substituted on the naphthyl ring to any extent, including
    • (i) 
      1-pentyl-3-(1-naphthoyl)indole (JWH-018)
    • (ii) 
      1-butyl-3-(1-naphthoyl)indole (JWH-073)
    • (iii) 
      1-pentyl-3-(4-methyl-1-naphthoyl)indole (JWH-122)
    • (iv) 
      1-hexyl-3-(1-naphthoyl)indole (JWH-019)
    • (v) 
      1-(4-pentenyl)-3-(1-naphthoyl)indole (JWH-022)
    • (vi) 
      1-butyl-3-(4-methoxy-1-naphthoyl)indole (JWH-080)
    • (vii) 
      1-pentyl-3-(4-methoxy-1-naphthoyl)indole (JWH-081)
    • (viii) 
      1-(2-morpholin-4-ylethyl)-3-(1-naphthoyl)indole (JWH-200)
    • (ix) 
      1-pentyl-3-(4-ethyl-1-naphthoyl)indole (JWH-210)
    • (x) 
      1-pentyl-3-(2-methoxy-1-naphthoyl)indole (JWH-267)
    • (xi) 
      1-[(N-methylpiperidin-2-yl)methyl]-3-(1-naphthoyl)indole (AM-1220)
    • (xii) 
      1-(5-fluoropentyl)-3-(1-naphthoyl)indole (AM-2201)
    • (xiii) 
      1-(5-fluoropentyl)-3-(4-methyl-1-naphthoyl)indole (MAM-2201)
    • (xiv) 
      1-(5-fluoropentyl)-3-(4-ethyl-1-naphthoyl)indole (EAM-2201)
    • (xv) 
      ((3R)-2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl)-1-naphthalenyl-methanone (WIN 55,212-2)
  • (3) 
    Any substance that has a 3-(1-naphthoyl)pyrrole structure with substitution at the nitrogen atom of the pyrrole ring, whether or not further substituted on the pyrrole ring to any extent and whether or not substituted on the naphthyl ring to any extent, including
    • (i) 
      1-pentyl-5-(2-fluorophenyl)-3-(1-naphthoyl)pyrrole (JWH-307)
  • (4) 
    Any substance that has a 3-phenylacetylindole structure with substitution at the nitrogen atom of the indole ring, whether or not further substituted on the indole ring to any extent and whether or not substituted on the phenyl ring to any extent, including
    • (i) 
      1-pentyl-3-(2-methoxyphenylacetyl)indole (JWH-250)
    • (ii) 
      1-pentyl-3-(2-methylphenylacetyl)indole (JWH-251)
    • (iii) 
      1-pentyl-3-(3-methoxyphenylacetyl)indole (JWH-302)
  • (5) 
    Any substance that has a 3-benzoylindole structure with substitution at the nitrogen atom of the indole ring, whether or not further substituted on the indole ring to any extent and whether or not substituted on the phenyl ring to any extent, including
    • (i) 
      1-(1-methylpiperidin-2-ylmethyl)-3-(2-iodobenzoyl)indole (AM-2233)
  • (6) 
    Any substance that has a 3-methanone(cyclopropyl)indole structure with substitution at the nitrogen atom of the indole ring, whether or not further substituted on the indole ring to any extent and whether or not substituted on the cyclopropyl ring to any extent, including
    • (i) 
      (1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)-methanone (UR-144)
    • (ii) 
      (1-(5-fluoropentyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)-methanone (5F-UR-144)
    • (iii) 
      (1-(2-(4-morpholinyl)ethyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)-methanone (A-796,260)
  • (7) 
    Any substance that has a quinolin-8-yl 1H-indole-3-carboxylate structure with substitution at the nitrogen atom of the indole ring, whether or not further substituted on the indole ring to any extent and whether or not substituted on the quinolin-8-yl ring to any extent, including
    • (i) 
      1-pentyl-8-quinolinyl ester-1H-indole-3-carboxylic acid (PB-22)
    • (ii) 
      1-(5-fluoropentyl)-8-quinolinyl ester-1H-indole-3-carboxylic acid (5F-PB-22)
  • (8) 
    Any substance that has a 3-carboxamideindazole structure with substitution at the nitrogen atom of the indazole ring, whether or not further substituted on the indazole ring to any extent and whether or not substituted at the carboxamide group to any extent, including
    • (i) 
      N-(adamantan-1-yl)-1-pentyl-1H-indazole-3-carboxamide (AKB48)
    • (ii) 
      N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide (5F-AKB48)
    • (iii) 
      N-(1-(aminocarbonyl)-2-methylpropyl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide (AB-FUBINACA)
    • (iv) 
      N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide (AB-PINACA)
  • (9) 
    Any substance that has a 3-carboxamideindole structure with substitution at the nitrogen atom of the indole ring, whether or not further substituted on the indole ring to any extent and whether or not substituted at the carboxamide group to any extent, including
    • (i) 
      N-(adamantan-1-yl)-1-fluoropentylindole-3-carboxamide (STS-135)
    • (ii) 
      N-(adamantan-1-yl)-1-pentylindole-3-carboxamide (APICA)
18Tapentadol (3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl]-phenol), its salts, derivatives and isomers and salts of derivatives and isomers
19Tramadol (2-[(dimethylamino)methyl]-1-(3- methoxyphenyl)cyclohexanol), its salts, isomers and salts of isomers and the following derivatives of tramadol and the salts, isomers and salts of isomers of those derivatives:
  • (1) 
    O-desmethyltramadol (3-[2- [(dimethylamino)methyl]-1-hydroxycyclohexyl]-phenol)
  • (2) 
    N,O-didesmethyltramadol (3-[1-hydroxy-2- [(methylamino)methyl]cyclohexyl]-phenol)
20AP-237 (1-(4-cinnamylpiperazin-1-yl)butan-1-one), its salts, derivatives and analogues and salts of derivatives and analogues, including:
  • (1) 
    2-methyl-AP-237 (1-(4-cinnamyl-2-methylpiperazin-1-yl)butan-1-one)
  • (2) 
    para-methyl-AP-237 ((E)-1-(4-(3-(p-tolyl)allyl)piperazin-1-yl)butan-1-one)
  • (3) 
    AP-238 (1-(4-cinnamyl-2,6-dimethylpiperazin-1-yl)propan-1-one)
21Piritramide (1-(3-cyano-3,3-diphenylpropyl)-4-(1-piperidino)piperidine-4-carboxylic acid amide), its salts, derivatives and salts of derivatives
 

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