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Hazardous Products Regulations

Version of section 8.2.2 from 2022-12-15 to 2024-04-01:


Marginal note:Human data — skin corrosion

  •  (1) A substance for which human data demonstrate that it is a skin-corrosive substance is classified in the category “Skin Corrosion — Category 1”.

  • Marginal note:Animal data — skin corrosion

    (2) A substance for which purposely generated animal data demonstrate that it is a skin-corrosive substance is classified in the category “Skin Corrosion — Category 1” and is, if the applicable data are available, further classified in accordance with the following table:

    TABLE

    Column 1Column 2
    ItemSubcategoryCriteria
    1Skin Corrosion — Category 1AA substance that, according to animal data acquired from a scientifically validated method, produces irreversible damage to the skin after an exposure of three minutes or less, and within one hour of observation, in at least one animal
    2Skin Corrosion — Category 1BA substance that, according to animal data acquired from a scientifically validated method, produces irreversible damage to the skin after an exposure of more than three minutes and up to and including one hour, and within 14 days of observation, in at least one animal
    3Skin Corrosion — Category 1CA substance that, according to animal data acquired from a scientifically validated method, produces irreversible damage to the skin after an exposure of more than one hour and up to and including four hours, and within 14 days of observation, in at least one animal
  • Marginal note:Human or animal data — skin irritation

    (3) A substance for which there are human data or purposely generated animal data with respect to skin irritation is classified in the category “Skin Irritation — Category 2” in accordance with the following table:

    TABLE

    Column 1Column 2
    ItemCategoryCriteria
    1Skin Irritation — Category 2

    A substance

    • (a) that, according to human data, is skin-irritant; or

    • (b) in respect of which animal data reveal

      • (i) in the case of data acquired from a test performed in accordance with the OECD Guideline for the Testing of Chemicals, No. 404, entitled Acute Dermal Irritation/Corrosion, as amended from time to time, a mean score of ≥ 2.3 and ≤ 4.0 for erythema and eschar or for edema in at least two of three animals from gradings at 24, 48 and 72 hours after patch removal or, if reactions are delayed, from gradings on three consecutive days after the onset of skin reactions,

      • (ii) in the case of data acquired from a scientifically validated method, inflammation, namely, local alopecia, hyperkeratosis, hyperplasia and scaling, that persists to the end of the observation period specified by the method in at least two animals, or

      • (iii) in the case of data acquired from a scientifically validated method, evidence of severe skin irritation in only one animal

  • Marginal note:No classification

    (4) A substance that meets the following conditions need not be classified in any category or subcategory of this hazard class:

    • (a) there are human data or purposely generated animal data on the substance, acquired from a scientifically validated method, with respect to skin corrosion or skin irritation;

    • (b) the substance is not classified further to subsection (1), (2) or (3); and

    • (c) the data referred to in paragraph (a) demonstrate that it is neither a skin-corrosive substance nor a skin-irritant substance.

  • SOR/2022-272, s. 42

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