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Transportation of Dangerous Goods Regulations (SOR/2001-286)

Regulations are current to 2020-09-22 and last amended on 2020-02-19. Previous Versions

PART 2Classification (continued)

Class 6, Toxic and Infectious Substances (continued)

Determination of LD50 (oral or dermal) of a Mixture of Substances

 To determine the LD50 of a mixture of solid or liquid substances when the LD50 of each of the substances is known, use 1 000 mg/kg as the toxic limit and

  • (a) if the mixture contains only one substance with an LD50 less than or equal to the toxic limit (called “Substance A”), use the following calculation:

    LD50 of the mixture = (LD50 of Substance A) ÷ (fraction by mass of Substance A in the mixture)

or

  • (b) if the mixture contains more than one substance with an LD50 less than or equal to the toxic limit (called “Substance A”, “Substance B”, etc.),

    • (i) determine the lowest LD50 of all substances, assign that LD50 to all substances whose actual LD50 is less than or equal to the toxic limit, then use the calculation in paragraph (a) using that assigned LD50 and taking as the mass of Substance A in the formula the total of the masses of all substances whose actual LD50 is less than or equal to the toxic limit, or

    • (ii) use the following calculations:

      • (A) determine the contributing number (CN) of each of the substances with an LD50 less than or equal to the toxic limit using the formula

        CN for Substance A= (LD50 of Substance A) ÷ (fraction by mass of Substance A in the mixture)

      • (B) combine the contributing numbers (CN) of each substance with an LD50 less than or equal to the toxic limit as

        T = 1 ÷ (CN Substance A) + 1 ÷ (CN Substance B) + (as needed)

      and

      • (C) obtain the LD50 of the mixture by dividing 1 by the number T (LD50 of the mixture = 1 / T).

Determination of LC50 (dust, mist or vapour)

 LC50 values for a substance in the form of a dust, mist or vapour or for a mixture of substances in the form of a dust, mist or vapour must be determined

  • (a) by using the LC50 values published in technical journals or in government publications;

  • (b) in accordance with sections 2.6.2.2.4.2 to 2.6.2.2.4.7 of Chapter 2.6 of the UN Recommendations; or

  • (c) for a mixture of substances, in accordance with section 2.33.

Determination of LC50 (dust, mist or vapour) of a Mixture of Substances

 To determine the LC50 of a mixture of substances that are in the form of a dust, mist or vapour, when the LC50 of each of the substances is known, make the determination in accordance with section 2.17, except that for a dust use 10 mg/L as the toxic limit and for a mist use 2 mg/L as the toxic limit. For a substance in the form of vapour the toxic limit is the same as for a gas, which is 5 000 mL/m3.

  • SOR/2002-306, s. 13

Determination of the Packing Group of a Mixture of Liquids with an Inhalation Toxicity by Vapour

  •  (1) The first step in determining the packing group of a mixture of liquids with an inhalation toxicity by vapour when one or more of the substances has an LC50 (vapour) less than or equal to 5 000 mL/m3, and the LC50 of each substance is known, is to determine the following data:

    • (a) determine the LC50 (vapour) for the mixture in accordance with section 2.33;

    • (b) where Pi is the vapour pressure of the ith substance in kPa at 20°C and an absolute pressure of 101.3 kPa, determine the volatility, Vi, of each substance in the mixture as

      Vi = Pi multiplied by 106 then divided by 101.3;

    • (c) determine the ratio of the volatility of a substance to its LC50 for each substance with an LC50 less than or equal to 5 000 mL/m3 as

      Ri = Vi divided by the LC50 of the ith substance;

    and

    • (d) set R equal to the sum of the Ri for each of the substances with an LC50 less than or equal to 5 000 mL/m3 as

      R = R1 + R2 + ... + (as needed).

  • (2) Using the data determined in accordance with subsection (1), the mixture is included in one of the following packing groups:

    • (a) Packing Group I, if

      • (i) R is greater than or equal to 10, and

      • (ii) the LC50 (mixture) is less than or equal to 1 000 mL/m3;

    • (b) Packing Group II, if

      • (i) R is greater than or equal to 1,

      • (ii) the LC50 (mixture) is less than or equal to 3 000 mL/m3, and

      • (iii) the criteria for inclusion in Packing Group I are not met; or

    • (c) Packing Group III, if

      • (i) R is greater than or equal to 0.2,

      • (ii) the LC50 (mixture) is less than or equal to 5 000 mL/m3, and

      • (iii) the criteria for inclusion in Packing Group I or II are not met.

Determination of the Packing Group of a Mixture of Liquids with an Inhalation Toxicity and an Unknown LC50

  •  (1) A mixture of liquids with an inhalation toxicity and an unknown LC50 is included in Packing Group I if it meets the following criteria:

    • (a) when a sample of the mixture is vapourized and diluted with air to create a test atmosphere of 1 000 mL/m3 and 10 young adult albino rats (5 male and 5 female) are exposed to the test atmosphere for 1 hour and observed for 14 days, the result is the death of 5 or more of the animals within the 14-day observation period; and

    • (b) when a sample of the vapour in equilibrium with the mixture at 20°C is diluted with 9 equal volumes of air to form a test atmosphere and 10 young adult albino rats (5 male and 5 female) are exposed to the test atmosphere for 1 hour and observed for 14 days, the result is the death of 5 or more of the animals within the 14-day observation period.

  • (2) A mixture of liquids with an inhalation toxicity and an unknown LC50 is included in Packing Group II if it meets the following criteria and the criteria for inclusion in Packing Group I are not met:

    • (a) when a sample of the mixture is vapourized and diluted with air to create a test atmosphere of 3 000 mL/m3 and 10 young adult albino rats (5 male and 5 female) are exposed to the test atmosphere for 1 hour and observed for 14 days, the result is the death of 5 or more of the animals within the 14-day observation period; and

    • (b) when a sample of the vapour in equilibrium with the mixture at 20°C is used to form a test atmosphere and 10 young adult albino rats (5 male and 5 female) are exposed to the test atmosphere for 1 hour and observed for 14 days, the result is the death of 5 or more of the animals within the 14-day observation period.

  • (3) A mixture of liquids with an inhalation toxicity and an unknown LC50 is included in Packing Group III if it meets the following criteria and the criteria for inclusion in Packing Group I or II are not met:

    • (a) when a sample of the mixture is vapourized and diluted with air to create a test atmosphere of 5 000 mL/m3 and 10 young adult albino rats (5 male and 5 female) are exposed to the test atmosphere for 1 hour and observed for 14 days, the result is the death of 5 or more of the animals within the 14-day observation period; and

    • (b) when the vapour pressure of the mixture is measured, the vapour concentration is greater than or equal to 1 000 mL/m3.

  • (4) If only LC50 data relating to 4-hour exposures to dust or mist are available, those figures can be multiplied by 4 and the result taken as the LC50 data for 1 hour, that is LC50 4 hours (dust or mist) multiplied by 4 is equivalent to LC50 1 hour.

  • (5) If only LC50 data relating to 4-hour exposures to vapour are available, those figures can be multiplied by 2 and the result taken as the LC50 data for 1 hour, that is LC50 4 hours (vapour) multiplied by 2 is equivalent to LC50 1 hour.

Infectious Substances

  •  (1) Substances are included in Class 6.2, Category A or Category B if they are infectious substances and are listed in Appendix 3 to this Part or exhibit characteristics similar to a substance listed in that appendix.

  • (2) Infectious substances that are included in Category A and that are in a form other than a culture may be handled, offered for transport or transported as Category B in accordance with the conditions set out in paragraphs 1.39(a) to (c) of Part 1 (Coming into Force, Repeal, Interpretation, General Provisions and Special Cases).

  • (3) Despite subsection (2), the following infectious substances included in Category A, and any substance that exhibits characteristics similar to these substances, must always be handled, offered for transport or transported as Category A:

    • (a) Crimean-Congo Hemorrhagic fever virus;

    • (b) Ebola virus;

    • (c) Flexal virus;

    • (d) Guanarito virus;

    • (e) Hantaviruses causing hemorrhagic fever with renal syndrome;

    • (f) Hantaviruses causing pulmonary syndrome;

    • (g) Hendra virus;

    • (h) Herpes B virus (Cercopithecine Herpesvirus-1);

    • (i) Junin virus;

    • (j) Kyasanur Forest virus;

    • (k) Lassa virus;

    • (l) Machupo virus;

    • (m) Marburg virus;

    • (n) Monkeypox virus;

    • (o) Nipah virus;

    • (p) Omsk hemorrhagic fever virus;

    • (q) Russian Spring – Summer encephalitis virus;

    • (r) Sabia virus; and

    • (s) Variola (smallpox virus).

  • SOR/2008-34, s. 36
 
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