Consumer Chemicals and Containers Regulations, 2001 (SOR/2001-269)

Determination of Toxicity

Marginal note:Data sources

• 35 (1) The responsible person for a toxic product must determine, from one or more of the following data sources in the following order of precedence, its toxicity or, in the case of a mixture that separates, the toxicity of each layer of the mixture:

  • (a) the LD₅₀ or LC₅₀ or both, as the case may be, of the product or of the layer as determined by the peer-reviewed results of acute toxicity tests using the product on animals, which tests were conducted in accordance with the OECD Test Guidelines for acute toxicity testing;

  • (b) if tests on animals using the product have not been conducted in accordance with the OECD Test Guidelines for acute toxicity testing, the LD₅₀ or LC₅₀ or both, as the case may be, of the product or of the layer as determined by

    • (i) peer-reviewed results of acute toxicity tests of the product or the layer, which tests were conducted on animals in accordance with

      • (A) a National Standard or an international standard recognized by the Standards Council of Canada, or

      • (B) a generally accepted procedure that conformed with good scientific practices at the time the tests were conducted,

    • (ii) if the product is a mixture that does not separate, section 36,

    • (iii) peer-reviewed results of tests of a chemical product or a substance that has similar properties to those of the product or of the layer under examination, which tests were conducted on animals in accordance with

      • (A) OECD Test Guidelines for acute toxicity testing,

      • (B) a National Standard or an international standard recognized by the Standards Council of Canada, or

      • (C) a generally accepted procedure that conformed with good scientific practices at the time the tests were conducted, or

    • (iv) other current, peer-reviewed information about the product or the layer; or

  • (c) the LD₅₀ or LC₅₀ or both, as the case may be, of the product or of the layer as determined by the results of tests conducted with the toxic product by the responsible person in accordance with a test methodology that conforms with good scientific practices.

• Marginal note:Differing data sources

  (2) In the case of differing data sources,

  • (a) an original literature source must be used in preference to a literature source that refers to the original study; and

  • (b) a source that reports test results that conform with good scientific practices and that disclose the greatest hazard must be used.

• Marginal note:Mixture that separates

  (3) In the case of a mixture that separates, the toxic product must be assigned the LD₅₀ or LC₅₀ or both, as the case may be, of the most toxic layer.

• Definition of mixture that separates

  (4) In this section, mixture that separates means a chemical product in a liquid or semi-liquid state that separates into two or more distinct layers if left standing undisturbed for a period of 30 days at 20^oC.

Marginal note:Additivity formulas — LD₅₀ or LC₅₀ of mixtures

• 36 (1) The LD₅₀ or LC₅₀ of a mixture may be determined from the LD₅₀ or LC₅₀ of its ingredients that are present in a concentration of 1% or more, using one of the following additivity formulas, as the case may be:

  • (a) for a solid or a liquid

    LD₅₀ = 1/[(P_a/LD_50a)+(P_b/LD_50b)+...+(P_n/LD_50n)]

    where

    LD₅₀

    represents the LD₅₀ of the mixture,

    LD_50a to LD_50n

    represent the LD₅₀ of each ingredient that is present in a concentration of 1% or more, and

    P_a to P_n

    represent the proportion by weight of each ingredient that is present in a concentration of 1% or more; or

  • (b) for a gas, vapour, dust, mist or fume

    LC₅₀ = 1/[(P_a/LC_50a)+(P_b/LC_50b)+...+(P_n/LC_50n)]

    where

    LC₅₀

    represents the LC₅₀ of the mixture,

    LC_50a to LC_50n

    represent the LC₅₀ of each ingredient that is present in a concentration of 1% or more, and

    P_a to P_n

    represent the proportion by weight of each ingredient that is present in a concentration of 1% or more.

• Marginal note:Complex mixture

  (2) For the purposes of the additivity formulas set out in subsection (1), “ingredient” includes a complex mixture.

• Marginal note:When LD₅₀ or LC₅₀ of ingredient is not known but can be estimated

  (3) When the LD₅₀ or LC₅₀ of one or more ingredients present in a chemical product in a concentration of 1% or more is not known, the responsible person may, in the additivity formulas set out in subsection (1), use an estimated LD₅₀ or LC₅₀ determined in accordance with good scientific practices.

• Marginal note:When LD₅₀ or LC₅₀ of ingredient is not known and cannot be estimated

  (4) When the LD₅₀ or LC₅₀ of one or more ingredients present in a chemical product is not known and cannot be estimated from information referred to in paragraph 35(1)(b) or (c), the responsible person, in the additivity formulas set out in subsection (1), must substitute for the LD₅₀ or LC₅₀ of the ingredient, the LD₅₀ or LC₅₀ of the most toxic known ingredient that is present in the product at a concentration of 1% or more.

Marginal note:Conversion to a 4-hour LC₅₀

37 An LC₅₀ obtained during a duration of exposure of other than four hours must be converted to an LC₅₀ equivalent to a duration of exposure of four hours by using one of the following formulas, as the case may be:

• (a) for a gas or vapour

  LC_{50 of 4 hours} = (LC_50y)(y^½/2)

  where

  LC_{50 of 4 hours}

  represents the LC₅₀ of the mixture for a duration of exposure of four hours,

  LC_50y

  represents the LC₅₀ of the mixture for a duration of exposure of y hours, and

  y

  represents the actual duration of exposure expressed in hours and must be no greater than 10 hours; or

• (b) for a dust, mist or fume

  LC_{50 of 4 hours} = (LC_50y)(y/4)

  where

  LC_{50 of 4 hours}

  represents the LC₅₀ of the mixture for a duration of exposure of four hours,

  LC_50y

  represents the LC₅₀ of the mixture for a duration of exposure of y hours, and

  y

  represents the actual duration of exposure expressed in hours and must be no greater than 10 hours.

Very Toxic Products

Marginal note:Prohibition

38 The manufacturing, importation, advertising or sale of a chemical product that is classified in the sub-category “very toxic” under section 33 is prohibited.

Required Information

Marginal note:Required information — sub-category “toxic”

• 39 (1) The container of a chemical product that is classified in the sub-category “toxic” under section 33 must display, for each type of information set out in column 1 of the table to this subsection, and for each applicable route of exposure set out in column 2, the information set out in columns 3 and 4, other than the instructions set out in italics.

  	Column 1	Column 2	Column 3	Column 4
  Item	Type of information	Applicable route of exposure	English information	French information
  1	Hazard symbol	All
  2	Signal word	All	DANGER	DANGER
  3	Primary hazard statement	All	POISON	POISON
  4	Specific hazard statement	(a) Oral or aspiration	CONTENTS HARMFUL	CONTENU NOCIF
  		(b) Dermal	CONTENTS HARMFUL	CONTENU NOCIF
  		(c) Inhalation	CONTENTS HARMFUL or, if only the vapour or fume poses a hazard: FUMES HARMFUL	CONTENU NOCIF or, if only the vapour or fume poses a hazard: ÉMANATIONS NOCIVES
  5	Negative instructions	(a) Oral or aspiration	Do not swallow.	Ne pas avaler.
  		(b) Oral and contains 1% or more methyl alcohol and a total quantity of 5 mL or more	May cause blindness if swallowed.	L’ingestion peut causer la cécité.
  		(c) Dermal	Do not get in eyes or on skin or clothing.	Éviter tout contact avec les yeux, la peau et les vêtements.
  		(d) Inhalation	Do not breathe fumes.	Ne pas respirer les émanations.
  6	Positive instructions	(a) All	Keep out of reach of children.	Tenir hors de la portée des enfants.
  		(b) Oral or aspiration	Wear [Insert description of the specific safety equipment relevant to the hazard, e.g., a mask.].	Porter [Insert description of the specific safety equipment relevant to the hazard, e.g., un masque.].
  		(c) Dermal	Wear [Insert description of the specific safety equipment relevant to the hazard, e.g., rubber gloves, safety glasses.].	Porter [Insert description of the specific safety equipment relevant to the hazard, e.g., des gants de caoutchouc, des lunettes de sécurité.].
  		(d) Inhalation	Use only in a well-ventilated area. Wear [Insert description of the specific safety equipment relevant to the hazard, e.g., a mask, a respirator.].	N’utiliser que dans un endroit bien aéré. Porter [Insert description of the specific safety equipment relevant to the hazard, e.g., un masque, un respirateur.].
  7	First aid statement	(a) All	FIRST AID TREATMENT Contains [name of hazardous ingredients in descending order of proportion]. If swallowed, call a Poison Control Centre or doctor immediately.	PREMIERS SOINS Contient [name of hazardous ingredients in descending order of proportion]. En cas d’ingestion, appeler immédiatement un centre antipoison ou un médecin.
  		(b) Oral or aspiration	When appropriate, [Insert instructions for administering first aid, e.g., Do not induce vomiting.].	When appropriate, [Insert instructions for administering first aid, e.g., Ne pas provoquer le vomissement.].
  		(c) Dermal	If in eyes or on skin, rinse well with water. If on clothes, remove clothes.	En cas de contact avec les yeux ou la peau, bien rincer avec de l’eau. En cas de contact avec les vêtements, enlever ceux-ci.
  		(d) Inhalation	If breathed in, move person into fresh air.	En cas d’inhalation, transporter à l’air frais la personne exposée.

• Marginal note:Required information — sub-category “harmful”

  (2) The container of a chemical product that is classified in the sub-category “harmful” under section 33 must display, for each type of information set out in column 1 of the table to this subsection, and for each applicable route of exposure set out in column 2, the information set out in columns 3 and 4, other than the instructions set out in italics.

  	Column 1	Column 2	Column 3	Column 4
  Item	Type of information	Applicable route of exposure	English information	French information
  1	Hazard symbol	All
  2	Signal word	All	CAUTION	ATTENTION
  3	Primary hazard statement	All	POISON	POISON
  4	Specific hazard statement	(a) Oral or aspiration	CONTENTS MAY BE HARMFUL	LE CONTENU PEUT ÊTRE NOCIF
  		(b) Dermal	CONTENTS MAY BE HARMFUL	LE CONTENU PEUT ÊTRE NOCIF
  		(c) Inhalation	CONTENTS MAY BE HARMFUL or, if only the vapour or fume poses a hazard: FUMES MAY BE HARMFUL	LE CONTENU PEUT ÊTRE NOCIF or, if only the vapour or fume poses a hazard: LES ÉMANATIONS PEUVENT ÊTRE NOCIVES
  5	Negative instructions	(a) Oral or aspiration	Do not swallow.	Ne pas avaler.
  		(b) Dermal	Do not get in eyes or on skin or clothing.	Éviter tout contact avec les yeux, la peau et les vêtements.
  		(c) Inhalation	Do not breathe fumes.	Ne pas respirer les émanations.
  6	Positive instructions	(a) All	Keep out of reach of children.	Tenir hors de la portée des enfants.
  		(b) Oral or aspiration	Wear [Insert description of the specific safety equipment relevant to the hazard, e.g., a mask.].	Porter [Insert description of the specific safety equipment relevant to the hazard, e.g., un masque.].
  		(c) Dermal	Wear [Insert description of the specific safety equipment relevant to the hazard, e.g., rubber gloves, safety glasses.].	Porter [Insert description of the specific safety equipment relevant to the hazard, e.g., des gants de caoutchouc, des lunettes de sécurité.].
  		(d) Inhalation	Use only in a well-ventilated area. Wear [Insert description of the specific safety equipment relevant to the hazard, e.g., a mask, a respirator.].	N’utiliser que dans un endroit bien aéré. Porter [Insert description of the specific safety equipment relevant to the hazard, e.g., un masque, un respirateur.].
  7	First aid statement	(a) All	FIRST AID TREATMENT Contains [name of hazardous ingredients in descending order of proportion]. If swallowed, call a Poison Control Centre or doctor immediately.	PREMIERS SOINS Contient [name of hazardous ingredients in descending order of proportion]. En cas d’ingestion, appeler immédiatement un centre antipoison ou un médecin.
  		(b) Oral or aspiration	When appropriate, [Insert instructions for administering first aid, e.g., Do not induce vomiting.].	When appropriate, [Insert instructions for administering first aid, e.g., Ne pas provoquer le vomissement.].
  		(c) Dermal	If in eyes or on skin, rinse well with water. If on clothes, remove clothes.	En cas de contact avec les yeux ou la peau, bien rincer avec de l’eau. En cas de contact avec les vêtements, enlever ceux-ci.
  		(d) Inhalation	If breathed in, move person into fresh air.	En cas d’inhalation, transporter à l’air frais la personne exposée.

• (3) [Repealed, SOR/2009-165, s. 12]